ASTM E1163-1998(2002) 评定剧毒口服灭鼠剂的试验方法
作者:标准资料网
时间:2024-05-04 15:43:08
浏览:9544
来源:标准资料网
下载地址: 点击此处下载
【英文标准名称】:StandardTestMethodforEstimatingAcuteOralToxicityinRats
【原文标准名称】:评定剧毒口服灭鼠剂的试验方法
【标准号】:ASTME1163-1998(2002)
【标准状态】:现行
【国别】:
【发布日期】:1998
【实施或试行日期】:
【发布单位】:美国材料与试验协会(US-ASTM)
【起草单位】:E47.02
【标准类型】:(TestMethod)
【标准水平】:()
【中文主题词】:农药;病虫害防治;试验;污染控制;危险物质;杀鼠剂;毒性
【英文主题词】:chemicals;LD50;oraltoxicity;pesticides;rats
【摘要】:Thistestmethodisofprincipalvalueinminimizingthenumberofanimalsrequiredtoestimatetheacuteoraltoxicity(LD50).Thistestmethodisinappropriateformaterialstypicallyproducingdeath2ormoredaysafteradministrationofthetestcompoundunlesstheobservationtimebetweendosagesisincreased.Thistestmethodcanbesuccessfullyapplied,however,formaterialsproducingonlyanoccasionaldeath2ormoredaysafteradministration.TheLD50isvaluableasameasureoftherelativeacutetoxicityofamaterialandcanbeusedtomakeanestimateofpotentialhazardtohumanswhenpesticides,otherchemicals,ormixturesareingested.Thistestmethodallowsforobservationofsignsoftoxicityinadditiontomortality.Thisinformationcanbeusefulinplanningadditionaltoxicitytesting.1.1Thistestmethoddeterminesthelethality(LD50value)andsignsofacutetoxicityfromamaterialusingalimitednumberofrats.Thetechniqueusedinthistestmethodisreferredtoasthe"Up-and-DownProcedure."ThistestmethodisanalternativetotheclassicalLD50testandisapplicabletobothliquidsandsolids.1.2Thistestmethodisnotrecommendedfortestmaterialswhichtypicallyproducedeathsbeyond2dayspostdosing.1.3Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablishappropriatesafetyandhealthpracticesanddeterminetheapplicabilityofregulatorylimitationspriortouse.
【中国标准分类号】:G25
【国际标准分类号】:65_100_99
【页数】:3P.;A4
【正文语种】:
【原文标准名称】:评定剧毒口服灭鼠剂的试验方法
【标准号】:ASTME1163-1998(2002)
【标准状态】:现行
【国别】:
【发布日期】:1998
【实施或试行日期】:
【发布单位】:美国材料与试验协会(US-ASTM)
【起草单位】:E47.02
【标准类型】:(TestMethod)
【标准水平】:()
【中文主题词】:农药;病虫害防治;试验;污染控制;危险物质;杀鼠剂;毒性
【英文主题词】:chemicals;LD50;oraltoxicity;pesticides;rats
【摘要】:Thistestmethodisofprincipalvalueinminimizingthenumberofanimalsrequiredtoestimatetheacuteoraltoxicity(LD50).Thistestmethodisinappropriateformaterialstypicallyproducingdeath2ormoredaysafteradministrationofthetestcompoundunlesstheobservationtimebetweendosagesisincreased.Thistestmethodcanbesuccessfullyapplied,however,formaterialsproducingonlyanoccasionaldeath2ormoredaysafteradministration.TheLD50isvaluableasameasureoftherelativeacutetoxicityofamaterialandcanbeusedtomakeanestimateofpotentialhazardtohumanswhenpesticides,otherchemicals,ormixturesareingested.Thistestmethodallowsforobservationofsignsoftoxicityinadditiontomortality.Thisinformationcanbeusefulinplanningadditionaltoxicitytesting.1.1Thistestmethoddeterminesthelethality(LD50value)andsignsofacutetoxicityfromamaterialusingalimitednumberofrats.Thetechniqueusedinthistestmethodisreferredtoasthe"Up-and-DownProcedure."ThistestmethodisanalternativetotheclassicalLD50testandisapplicabletobothliquidsandsolids.1.2Thistestmethodisnotrecommendedfortestmaterialswhichtypicallyproducedeathsbeyond2dayspostdosing.1.3Thisstandarddoesnotpurporttoaddressallofthesafetyconcerns,ifany,associatedwithitsuse.Itistheresponsibilityoftheuserofthisstandardtoestablishappropriatesafetyandhealthpracticesanddeterminetheapplicabilityofregulatorylimitationspriortouse.
【中国标准分类号】:G25
【国际标准分类号】:65_100_99
【页数】:3P.;A4
【正文语种】:
下载地址:
点击此处下载